منابع مشابه
Septins
Septins are a family of proteins highly conserved in eukaryotes that have been under intense scrutiny lately because they appear to comprise a novel component of the cytoskeleton. As such, septins play important roles in many cellular processes by providing rigidity to the cell membrane, serving as scaffolds to recruit proteins to specific subcellular locales, and creating membrane diffusion ba...
متن کاملSwitching septins spurs sporulation
Septins are a family of GTP-binding proteins that, in most fungi and animals, form hetero-octameric rods containing two copies each of four different family members. These rods can then assemble into higher-order structures that perform a variety of cellular functions, depending on their subunit composition. The human genome, for example, encodes 13 different septins expressed by specifi c cell...
متن کاملCytoskeleton: Cirque du Septins
Septins and F-actin are familiar cohabitants of the cleavage furrow yet how they might be functionally connected has been ambiguous. New work shows that septins can promote the assembly of curved bundles of F-actin, providing an unexpected molecular function for septins in cytokinesis.
متن کاملSeptins at a glance.
The pioneering cell division cycle screens carried out by Hartwell in 1971 first identified septins as genes that are essential for yeast cytokinesis (Hartwell, 1971). However, significant characterization of the evolutionarily conserved proteins they encode did not begin until the late 1980s. Since then, septins have been shown to be fundamental for cytokinesis in many organisms and are recogn...
متن کاملMicrotubules follow septins’ guidelines
Microtubules follow septins' guidelines T he microtubules inside an epithelial cell undergo dramatic rearrangements when the cell becomes part of a polarized epithelial sheet. On its own, an epithelial cell is fl at, and its microtubules radiate out from the centrosome. But, after forming contacts with neighboring cells, an epithelial cell rises up into a columnar shape, and its microtubules fo...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2006
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb.1752rr2